严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的501Y.V2变异株可逃避南非新冠康复者捐赠血浆的中和作用。
SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.
作者信息
Wibmer Constantinos Kurt, Ayres Frances, Hermanus Tandile, Madzivhandila Mashudu, Kgagudi Prudence, Oosthuysen Brent, Lambson Bronwen E, de Oliveira Tulio, Vermeulen Marion, van der Berg Karin, Rossouw Theresa, Boswell Michael, Ueckermann Veronica, Meiring Susan, von Gottberg Anne, Cohen Cheryl, Morris Lynn, Bhiman Jinal N, Moore Penny L
机构信息
National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
bioRxiv. 2021 Mar 1:2021.01.18.427166. doi: 10.1101/2021.01.18.427166.
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）501Y.V2（B.1.351）是一种导致新冠肺炎的新型冠状病毒谱系，其刺突蛋白的两个免疫显性结构域存在替换。在此，我们表明，表达501Y.V2刺突蛋白的假病毒能完全逃逸三类具有治疗相关性的抗体。这种假病毒还表现出对康复期血浆的中和作用（而非结合作用）具有显著至完全的逃逸。这些数据凸显了再次感染抗原性不同变体的可能性，并预示着基于刺突蛋白的疫苗效力降低。
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