National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Nat Med. 2021 Apr;27(4):622-625. doi: 10.1038/s41591-021-01285-x. Epub 2021 Mar 2.
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
SARS-CoV-2 501Y.V2（B.1.351）是一种新型冠状病毒，引起 COVID-19，其刺突蛋白的两个免疫显性结构域存在突变。在此，我们发现表达 501Y.V2 刺突蛋白的假病毒完全逃避了三类具有治疗意义的相关抗体。这种假病毒对恢复期血浆的中和作用也表现出显著至完全逃逸，但不影响其结合。这些数据突显了与抗原不同的变体再次感染的可能性，并预示着基于刺突蛋白的疫苗效果降低。
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