Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Parasitol Res. 2021 Mar;120(3):773-783. doi: 10.1007/s00436-021-07064-4. Epub 2021 Jan 27.
Macrocyclic lactones are frequently used dewormers in livestock farms around the world. Due to their wide spectrum of action against nematodes and arthropods and their practicality of application at very low doses, their use has become massive since their discovery. These compounds are eliminated in a large percentage in the feces of animals, causing adverse effects on coprophilic fauna. Several research groups around the world have been devoted to evaluating these effects on this fauna. The aim of this review is to register the adverse effects of the concentrations in which macrocyclic lactones are eliminated in the feces of domestic animals and the importance of the coprophilic and edaphilous fauna on the degradation of the feces of the animals. The documented data shows that the use of macrocyclic lactones has a high toxicological risk for the different species that colonize the dung, thus causing an adverse effect on its disintegration and its subsequent incorporation into the soil. Even so, more studies at the regional level and their standardization are necessary to make the comparison between different areas possible.
大环内酯类化合物是世界范围内家畜养殖场常用的驱虫剂。由于它们对线虫和节肢动物具有广泛的作用谱，并且在非常低的剂量下具有实用性，因此自发现以来，它们的使用量已经非常大。这些化合物在动物粪便中有很大比例被消除，对嗜粪动物群产生不利影响。世界各地的几个研究小组一直在致力于评估这些对这种动物群的影响。本综述的目的是记录大环内酯类化合物在家畜粪便中消除的浓度对其产生的不利影响，以及嗜粪和土壤动物群对动物粪便降解的重要性。有文献记录的数据表明，大环内酯类化合物的使用对栖息在粪便中的不同物种具有很高的毒理学风险，从而对其分解及其随后掺入土壤产生不利影响。即便如此，仍需要在区域层面进行更多的研究并对其进行标准化，以便能够对不同地区进行比较。
