Chen Xiaoxiao, Sun Chen, Liu Chang, Wu Jie
School of Life Science & Technology, China Pharmaceutical University, Nanjing 210000, Jiangsu, China.
Sheng Wu Gong Cheng Xue Bao. 2021 Jan 25;37(1):40-52. doi: 10.13345/j.cjb.200211.
In recent years, long non-coding RNA (lncRNA) has been proved to be involved in the regulation of biological processes at various levels, attracting research interests in life science. LncRNA possesses the unique capability and exert discrete effects on transcription, translation and post-translational modification of the target genes through interacting with DNA, RNA and protein. Current studies have revealed that lncRNA plays an important role in hepatic metabolism via diverse pathways. This review focuses on the function of lncRNA and its relationship with hepatic energy metabolism and the correlated diseases, to elucidate the underlying mechanisms and prospects of lncRNA researches.
近年来，长链非编码RNA（lncRNA）已被证明参与了多个层面的生物过程调控，引发了生命科学领域的研究兴趣。lncRNA具有独特的能力，通过与DNA、RNA和蛋白质相互作用，对靶基因的转录、翻译和翻译后修饰发挥不同的作用。目前的研究表明，lncRNA通过多种途径在肝脏代谢中发挥重要作用。本文综述聚焦于lncRNA的功能及其与肝脏能量代谢和相关疾病的关系，以阐明lncRNA研究的潜在机制和前景。
