National Reference Laboratory of Veterinary Drug Residues (HZAU), MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China.
MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China.
Med Res Rev. 2021 May;41(3):1751-1774. doi: 10.1002/med.21775. Epub 2020 Dec 24.
Obesity syndromes, characterized by abnormal lipid, cholesterol, and glucose metabolism, are detrimental to human health and cause many diseases, including obesity and type II diabetes. Increasing evidence has shown that long noncoding RNA (lncRNA), transcripts longer than 200 nucleotides that are not translated into proteins, play an important role in regulating abnormal metabolism in obesity syndromes. For the first time, we systematically summarize how lncRNA is involved in complex obesity metabolic syndromes, including the regulation of lipid, cholesterol, and glucose metabolism. Moreover, we discuss lncRNA involvement in food intake that mediates obesity syndromes. Furthermore, this review might shed new light on a lncRNA-based strategy for the prevention and treatment of obesity syndromes. Recent investigations support that lncRNA is a novel molecular target of obesity syndromes and should be emphasized. Namely, lncRNA plays a crucial role in the development of obesity syndrome process. Various lncRNAs are involved in the process of lipid, cholesterol, and glucose metabolism by regulating gene transcription, signaling pathway, and epigenetic modification of metabolism-related genes, proteins, and enzymes. Food intake could also induce abnormal expression of lncRNA associated with obesity syndrome, especially high-fat diet. Notably, some nanomolecules and natural extracts may target lncRNAs, associated with obesity syndrome, as a potential treatment for obesity syndromes.
肥胖症候群的特征是脂质、胆固醇和葡萄糖代谢异常，对人类健康有害，并导致许多疾病，包括肥胖症和 2 型糖尿病。越来越多的证据表明，长链非编码 RNA（lncRNA）是一种不翻译成蛋白质的长度超过 200 个核苷酸的转录本，在调节肥胖症候群中的异常代谢中发挥着重要作用。我们首次系统地总结了 lncRNA 如何参与复杂的肥胖代谢综合征，包括对脂质、胆固醇和葡萄糖代谢的调节。此外，我们还讨论了 lncRNA 在介导肥胖症候群的食物摄入中的作用。此外，这篇综述可能为基于 lncRNA 的肥胖症候群的预防和治疗提供新的思路。最近的研究支持 lncRNA 是肥胖症候群的一个新的分子靶点，应该受到重视。也就是说，lncRNA 在肥胖症候群的发展过程中起着关键作用。各种 lncRNA 通过调节与代谢相关的基因、蛋白质和酶的转录、信号通路和表观遗传修饰，参与脂质、胆固醇和葡萄糖代谢的过程。食物摄入也会导致与肥胖症候群相关的 lncRNA 异常表达，尤其是高脂肪饮食。值得注意的是，一些纳米分子和天然提取物可能将与肥胖症候群相关的 lncRNA 作为肥胖症候群的潜在治疗靶点。
