Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Contact Dermatitis. 2021 Jul;85(1):39-45. doi: 10.1111/cod.13795. Epub 2021 Feb 14.
The common contact allergens may change over time as the environmental exposure changes.
To identify the prevalence rates and changing trends of contact allergens in Taiwan over a 40-year period.
MATERIALS & METHODS: The patch testing results of a referral centre from 1978 to 2018 were retrospectively reviewed. The study population was divided into four groups according to 10-year intervals. The prevalence rates of contact sensitization to each agent and the clinical relevance were analysed. For patients with positive reactions to relevant allergens, the occupations and sites of dermatitis were analysed.
From 1978 to 2018, a total of 4005 patients underwent patch testing. Successively increasing trends of positive reactions to cobalt, fragrance mix I, and para-phenylenediamine (PPD) were found. Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) was an emerging contact allergen. Hairdressers, cosmetologists, and aromatherapists became the occupations most commonly having positive reactions in the most recent 10 years. In the first two decades, the face and neck were the most commonly affected areas. Later, hands became the most commonly affected sites.
The prevalence rates of positive reactions to cobalt, fragrance mix I, and PPD increased successively. MCI/MI was an emerging contact allergen of special concern.
随着环境暴露的变化，常见的接触过敏原可能会随时间而改变。
确定台湾在 40 年内接触过敏原的流行率和变化趋势。
回顾了 1978 年至 2018 年转诊中心的斑贴试验结果。根据 10 年间隔将研究人群分为四组。分析了每种变应原致敏的流行率和临床相关性。对于对相关变应原呈阳性反应的患者，分析了皮炎的职业和部位。
1978 年至 2018 年，共有 4005 名患者接受了斑贴试验。发现钴、香料混合物 I 和对苯二胺（PPD）的阳性反应呈逐渐增加的趋势。甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）是一种新出现的接触过敏原。理发师、美容师和芳香疗法师成为最近 10 年最常见的阳性反应职业。在前两个十年中，面部和颈部是最常受影响的部位。后来，手部成为最常见的受累部位。
钴、香料混合物 I 和 PPD 的阳性反应流行率依次增加。MCI/MI 是一种新出现的特别关注的接触过敏原。
