Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, Thailand.
Contact Dermatitis. 2019 Aug;81(2):124-129. doi: 10.1111/cod.13289. Epub 2019 May 21.
Contact allergen prevalences often change. Continual surveillance is necessary to detect trends in sensitization rates and emerging allergens.
To identify the prevalence of, and trends in, the positive reactions to each allergen in the baseline series during a 12-year period in Thailand.
The medical records of 2803 patients who underwent patch testing at the Contact Dermatitis Clinic, Siriraj Hospital, between 2006 and 2018, were retrospectively reviewed. The baseline series used by the clinic was adapted from the European and the International baseline series. The patch testing results were subdivided into 2-year blocks in order to compare the prevalences of each allergen.
The prevalences of positive reactions to nickel, fragrance mixes I and II, dichromate, cobalt, carba mix, methyldibromo glutaronitrile, paraben mix, neomycin sulfate, methylisothiazolinone (MI), epoxy resin, N-isopropyl-N-phenyl-4-phenylenediamine and the corticosteroids significantly decreased. Methylchloroisothiazolinone (MCI)/MI was the only allergen associated with a significant increase of positive reactions, from 2.4% to 10.7%. However, the proportion of positive reactions to MCI/MI decreased in the final 2-year period.
Approximately half of the substances in the screening patch test series showed a decline in the number of positive reactions, whereas MCI/MI showed an increasing prevalence.
接触过敏原的流行率经常发生变化。为了检测致敏率和新出现的过敏原的趋势，需要进行持续监测。
在泰国的 12 年期间，确定基线系列中每种过敏原的阳性反应率及其趋势。
回顾性分析了 2006 年至 2018 年期间在 Siriraj 医院接触性皮炎诊所接受斑贴试验的 2803 名患者的病历。该诊所使用的基线系列改编自欧洲和国际基线系列。将斑贴试验结果细分为 2 年一组，以比较每种过敏原的流行率。
镍、香料混合物 I 和 II、重铬酸盐、钴、卡巴混合物、甲基二溴戊二腈、对羟基苯甲酸酯混合物、硫酸新霉素、甲基异噻唑啉酮（MI）、环氧树脂、N-异丙基-N-苯基-4-苯二胺和皮质类固醇的阳性反应率显著降低。甲基氯异噻唑啉酮（MCI）/MI 是唯一与阳性反应显著增加相关的过敏原，从 2.4%增加到 10.7%。然而，MCI/MI 的阳性反应比例在最后 2 年期间有所下降。
大约一半的筛查斑贴试验系列中的物质阳性反应数量减少，而 MCI/MI 的阳性反应比例则增加。
