Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T1Z4, Canada.
Nanomedicine (Lond). 2021 Feb;16(3):189-204. doi: 10.2217/nnm-2020-0372. Epub 2021 Jan 27.
One of the underlying mechanisms of Parkinson's disease is the aggregation of α-synuclein proteins, including amyloids and Lewy bodies in the brain. To study the inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation. Molecular dynamics tools were utilized to simulate the influence of CNTs doped with phosphorus, nitrogen and bromine and nitrogen on the formation of α-synuclein amyloid. The CNTs exhibited strong interactions with α-synuclein, with phosphorus-doped CNTs having the most substantial interactions. Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson's disease. However, further and clinical investigations are required.
帕金森病的潜在机制之一是α-突触核蛋白的聚集，包括大脑中的淀粉样蛋白和路易体。为了研究掺杂碳纳米管（CNTs）对淀粉样蛋白聚集的抑制作用。利用分子动力学工具模拟了掺杂磷、氮和溴以及氮的 CNTs 对α-突触核蛋白淀粉样形成的影响。CNTs 与α-突触核蛋白表现出强烈的相互作用，其中磷掺杂的 CNTs 的相互作用最大。掺杂 CNTs，特别是磷掺杂碳纳米管，可以有效地阻止α-突触核蛋白淀粉样形成，因此，它可以被认为是治疗帕金森病的一种潜在方法。然而，还需要进一步的和临床研究。
