Hayes W C, Kirk H D, Gushow T S, Young J T
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Fundam Appl Toxicol. 1988 Jan;10(1):82-8. doi: 10.1016/0272-0590(88)90253-9.
Reproductive parameters in Fischer 344 rats were evaluated following inhalation of propylene oxide (PO) for two successive generations. Thirty male and 30 female rats were exposed to 0, 30, 100, or 300 ppm PO for 6 hr/day, 5 days/week for 14 weeks and then mated to produce the f1 litters. After weaning, 30 randomly selected f1 pups/sex/group were exposed to PO for 17 weeks and subsequently mated to produce the f2 litters. Reproductive parameters examined included fertility, litter size and neonatal growth, and survival. All adults and selected weanlings were examined for gross and histologic lesions. Toxicity due to PO was demonstrated by decreased body weights of parental f0 and f1 rats at 300 ppm. No treatment-related effects on fertility (mating or conception) were observed in either f0 or f1 matings. Neonatal survival indices for f1 or f2 litters revealed no treatment-related effects. Litter size was decreased in the f1 rats exposed to 100 ppm PO. However, the litter size in the 300 ppm group was comparable to the control group, and no effect on litter size was shown in PO-exposed f2 litters. Pup weights were unaffected by parental exposure to PO in either generation. Pathologic examination of adults and weanlings revealed no changes considered due to PO. Based on these results, it is concluded that inhalation exposure to PO at levels up to 300 ppm over two generations did not produce any adverse effects on reproductive function.
在连续两代吸入环氧丙烷（PO）后，对Fischer 344大鼠的生殖参数进行了评估。30只雄性和30只雌性大鼠每天暴露于0、30、100或300 ppm的PO中，每天6小时，每周5天，持续14周，然后交配产生F1代幼崽。断奶后，每组随机选择30只F1代幼崽/性别暴露于PO中17周，随后交配产生F2代幼崽。检查的生殖参数包括生育力、窝仔数和新生仔鼠生长及存活率。对所有成年大鼠和选定的断奶仔鼠进行大体和组织学损伤检查。300 ppm时，亲代F0和F1大鼠体重下降证明了PO的毒性。在F0或F1交配中均未观察到与处理相关的对生育力（交配或受孕）的影响。F1或F2代幼崽的新生仔鼠存活指数未显示与处理相关的影响。暴露于100 ppm PO的F1大鼠窝仔数减少。然而，300 ppm组的窝仔数与对照组相当，暴露于PO的F2代幼崽未显示对窝仔数有影响。两代中亲代暴露于PO均未影响幼崽体重。对成年大鼠和断奶仔鼠的病理检查未发现因PO导致的变化。基于这些结果，得出结论：两代吸入高达300 ppm的PO对生殖功能未产生任何不利影响。
