Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain.
Department of Internal Medicine, La Milagrosa Hospital, Madrid, Spain.
Strahlenther Onkol. 2021 May;197(5):429-437. doi: 10.1007/s00066-020-01743-4. Epub 2021 Jan 27.
Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus‑2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could play a role in reducing the inflammatory response in the lungs and relieve life-threatening symptoms.
We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy.
We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment.
Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier: NCT04394182.
自 2019 年冠状病毒病（COVID-19）大流行爆发以来，医疗保健系统已集中精力寻找治疗方法，以避免因 2 型冠状病毒（SARS-CoV-2）引起的严重急性呼吸道综合征的致命后果。全身治疗的益处和风险仍不清楚，仍有多项临床试验正在进行中。放射治疗可能在减轻肺部炎症反应和缓解危及生命的症状方面发挥作用。
我们设计了一项针对 COVID-19 的超低剂量放射治疗（ULTRA-COVID）的前瞻性研究，该研究针对患有肺炎、不符合有创机械通气条件且对药物治疗无改善的患者。
我们报告了两名 COVID-19 肺炎患者接受 ULTRA-COVID 治疗的初步结果。在一次放射治疗后，两名患者均出现了显著的临床反应和良好的放射学反应，导致两名患者在放射治疗后不到 2 周即出院。
初步的临床和放射学结果表明，用 ULTRA-COVID 治疗 COVID-19 肺炎可能有一定的益处。ClinicalTrials.gov 标识符：NCT04394182。
