Stiehl A, Raedsch R, Rudolph G
Department of Medicine, University of Heidelberg, Federal Republic of Germany.
Gastroenterology. 1988 May;94(5 Pt 1):1201-6. doi: 10.1016/0016-5085(88)90013-3.
The amount of bile acid excreted via an ileostomy at the end of the ileum should give an estimate of the amount of bile acid transported to the colon. In the present study, 8 patients with ileostomies at the end of the ileum but without disease or resection of the small intestine excreted 1690 +/- 205 mumol/day (mean +/- SEM) of bile acids from the ileostomies. In comparison with duodenal bile, cholic acid was increased at the end of the ileum and chenodeoxycholic acid decreased; in addition, bile acid sulfates were increased and bile acid glucuronides were decreased. When ursodeoxycholic acid, a bile acid that decreases biliary cholesterol saturation and dissolves gallstones, was administered at a dose of 500 mg to each subject, 59% +/- 8% (mean +/- SEM) of this bile acid was excreted within 24 h from the ileostomies. It is apparent from these studies that absorption of ursodeoxycholic acid from the small intestine is slower than previously anticipated and involves the entire small intestine and probably also the colon.
经回肠末端回肠造口排出的胆汁酸量应能估算出输送至结肠的胆汁酸量。在本研究中，8名回肠末端有回肠造口但无小肠疾病或切除术的患者，回肠造口每天排出1690±205微摩尔（平均值±标准误）的胆汁酸。与十二指肠胆汁相比，回肠末端胆酸增加，鹅去氧胆酸减少；此外，胆汁酸硫酸盐增加，胆汁酸葡糖醛酸酯减少。当向每位受试者给予剂量为500毫克的熊去氧胆酸（一种可降低胆汁胆固醇饱和度并溶解胆结石的胆汁酸）时，该胆汁酸的59%±8%（平均值±标准误）在24小时内从回肠造口排出。从这些研究中可以明显看出，熊去氧胆酸在小肠的吸收比之前预期的要慢，且涉及整个小肠，可能还包括结肠。
