Bagheri Reza, Ashtary-Larky Damoon, Elliott Bradley T, Willoughby Darryn S, Kargarfard Mehdi, Alipour Meysam, Lamuchi-Deli Nasrin, Kooti Wesam, Asbaghi Omid, Wong Alexei
Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Arch Physiol Biochem. 2023 Jun;129(3):821-828. doi: 10.1080/13813455.2021.1874020. Epub 2021 Jan 27.
Research has shown the modulations of Follistatin (FST) and Myostatin (MST) following weight loss. We evaluated the effects of gradual weight loss (GWL) and rapid weight loss (RWL) on serum MST, FST, and body composition in overweight and obese females. Thirty-six overweight and obese females successfully completed the study interventions: GWL ( = 18) or RWL ( = 18). Serum MST and FST concentrations, as well as anthropometric measurements, were collected at baseline and at the conclusion of each weight loss intervention. MST concentration significantly ( < .05) decreased in the GWL; while FST concentration, body fat percentage and skeletal muscle mass significantly declined in both conditions. The loss in skeletal muscle mass was significantly greater in RWL relative to GWL. GWL was more effective than RWL in preserving skeletal muscle mass in overweight and obese females. Moreover, GWL leads to declines in MST concentrations.
研究表明了减重后卵泡抑素（FST）和肌肉生长抑制素（MST）的调节情况。我们评估了渐进性体重减轻（GWL）和快速体重减轻（RWL）对超重和肥胖女性血清MST、FST及身体成分的影响。36名超重和肥胖女性成功完成了研究干预：GWL组（n = 18）或RWL组（n = 18）。在基线以及每次体重减轻干预结束时收集血清MST和FST浓度以及人体测量数据。GWL组中MST浓度显著降低（P < 0.05）；而在两种情况下FST浓度、体脂百分比和骨骼肌质量均显著下降。相对于GWL，RWL中骨骼肌质量的损失显著更大。在超重和肥胖女性中，GWL在保留骨骼肌质量方面比RWL更有效。此外，GWL导致MST浓度下降。
