The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females.

Research has shown the modulations of Follistatin (FST) and Myostatin (MST) following weight loss. We evaluated the effects of gradual weight loss (GWL) and rapid weight loss (RWL) on serum MST, FST, and body composition in overweight and obese females. Thirty-six overweight and obese females successfully completed the study interventions: GWL ( = 18) or RWL ( = 18). Serum MST and FST concentrations, as well as anthropometric measurements, were collected at baseline and at the conclusion of each weight loss intervention. MST concentration significantly ( < .05) decreased in the GWL; while FST concentration, body fat percentage and skeletal muscle mass significantly declined in both conditions. The loss in skeletal muscle mass was significantly greater in RWL relative to GWL. GWL was more effective than RWL in preserving skeletal muscle mass in overweight and obese females. Moreover, GWL leads to declines in MST concentrations.