Zhang Meixian, Shi Guifeng, Wang Shuang, He Xiaoqin, Tung Tao-Hsin, Chen Yahong, Ye Yafei
Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
Department of Preventive Health Care, Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
BMC Complement Med Ther. 2025 Jul 16;25(1):272. doi: 10.1186/s12906-025-05016-4.
This study examined whether the addition of meal replacement (MR)-assisted intermittent fasting increases the effectiveness of a lifestyle intervention.
In a nonrandomized intervention study, overweight and obese participants aged 18 to 60 years were recruited for weight management with MRs or lifestyle intervention alone (LIA) for 8 weeks. The outcomes were the percent change in body weight from baseline to weeks 4 and 8 and the associated changes in body composition (using a bioimpedance analyzer). Generalized estimating equation (GEE) models were used to compare outcomes between groups.
A total of 126 participants were recruited, and 74 participants in the MR group and 46 participants in the LIA group finished the intervention protocol. The mean age was 35.4 ± 9.7 years, and 75.4% were female. The baseline BMI was 26.6 ± 3.7 kg/m. At 4 weeks, the percent weight loss in the MR group was 6.3%, whereas it was 4.0% in the LIA group (P < 0.001). At 8 weeks, the percent weight loss in the MR group was 8.2%, whereas it was 5.8% in the LIA group (P = 0.004). The GEE models revealed no further differences in weight loss or related measurements between the groups, whereas the time effect was significant.
Our study demonstrated that lifestyle interventions can result in weight loss regardless of the use of MR-assisted intermittent fasting. This finding suggests that nutritional support needs to be provided during short-term weight loss interventions.
Chinese Clinical Trial Registry number: ChiCTR2500099520, Retrospectively registered 25 March 2025.
本研究探讨添加代餐辅助间歇性禁食是否能提高生活方式干预的效果。
在一项非随机干预研究中，招募了18至60岁的超重和肥胖参与者，采用代餐或单独的生活方式干预（LIA）进行体重管理，为期8周。结果指标为从基线到第4周和第8周体重的百分比变化以及身体成分的相关变化（使用生物电阻抗分析仪）。采用广义估计方程（GEE）模型比较两组间的结果。
共招募了126名参与者，代餐组74名参与者和LIA组46名参与者完成了干预方案。平均年龄为35.4±9.7岁，女性占75.4%。基线BMI为26.6±3.7kg/m²。在第4周时，代餐组的体重减轻百分比为6.3%，而LIA组为4.0%（P<0.001）。在第8周时，代餐组的体重减轻百分比为8.2%，而LIA组为5.8%（P=0.004）。GEE模型显示两组间在体重减轻或相关测量方面无进一步差异，而时间效应显著。
我们的研究表明，无论是否使用代餐辅助间歇性禁食，生活方式干预都能导致体重减轻。这一发现表明，在短期体重减轻干预期间需要提供营养支持。
中国临床试验注册中心编号：ChiCTR2500099520，于2025年3月25日追溯注册。
