来自[具体来源未给出]的具有前所未有的环系的二萜类化合物及其在溶酶体自噬途径中的活性。
Diterpenoids with an unprecedented ring system from and their activities in the lysosomal-autophagy pathway.
作者信息
Chen Yan-Ni, Ding Xiao, Li Dong-Mei, Sun Mao, Yang Lei, Zhang Yu, Di Ying-Tong, Fang Xin, Hao Xiao-Jiang
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Shanghai Key Laboratory of Plant Functional Genomics and Resources, Plant Science Research Center, Shanghai Chenshan Botanical Garden, Shanghai, P.R. China.
出版信息
Org Biomol Chem. 2021 Feb 25;19(7):1541-1545. doi: 10.1039/d0ob02414g.
Three novel jatrophane diterpenes, cyclojatrophanes A-C (1-3), were isolated from the seeds of Euphorbia peplus. Compounds 1-3 featured an unprecedented 5/5/5/11 tetracyclic ring system incorporating ditetrahydropyran rings. Their structures including their absolute configurations were established by extensive spectroscopic analysis, X-ray crystallographic experiments and chemical transformations. In addition, these compounds could significantly activate the lysosomal-autophagy pathway.
从泽漆种子中分离出三种新型麻风树烷二萜类化合物，即环麻风树烷A-C（1-3）。化合物1-3具有前所未有的5/5/5/11四环体系，包含二氢吡喃环。通过广泛的光谱分析、X射线晶体学实验和化学转化确定了它们的结构，包括其绝对构型。此外，这些化合物可显著激活溶酶体自噬途径。
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