Chen Yan-Ni, Ding Xiao, Li Dong-Mei, Lu Qing-Yun, Liu Shuai, Li Ying-Yao, Di Ying-Tong, Fang Xin, Hao Xiao-Jiang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Yunnan University, Kunming, People's Republic of China.
Nat Prod Bioprospect. 2021 Jun;11(3):357-364. doi: 10.1007/s13659-021-00301-4. Epub 2021 Mar 14.
Euphopepluanones F - K (1 - 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 - 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 - 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway.
从泽漆种子中分离出了四种新的麻风树型二萜类化合物——大戟二萜醇F-K（1-4），以及八种已知的二萜类化合物（5-12）。它们的结构是通过广泛的光谱分析和X射线晶体学实验确定的。通过LysoTracker Red染色评估了新化合物1-4诱导溶酶体生物发生的活性。化合物2显著诱导了溶酶体生物发生。此外，化合物2可以增加LC3斑点的数量，表明它可以激活溶酶体自噬途径。
