State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China.
Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550014, China.
J Asian Nat Prod Res. 2024 Aug;26(8):900-909. doi: 10.1080/10286020.2024.2345181. Epub 2024 May 16.
Nine jatrophane diterpenoids were isolated from the whole plant , including two new ones, helioscopnins A () and B (). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds , , , , , and significantly increased autophagic flux.
从全株植物中分离得到 9 个大戟二萜类化合物，包括 2 个新化合物 helioscopnins A()和 B()。通过全面的光谱数据分析和 ECD 计算阐明了它们的结构，包括绝对构型。所有化合物均通过使用 HM mCherry-GFP-LC3 细胞的流式细胞术评估对自噬流的生物活性。化合物、、、、、和显著增加了自噬流。
