Programa de Pos-Graduacao em Ciencias da Saude, Faculdade Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
Clinics (Sao Paulo). 2021 Jan 20;76:e2350. doi: 10.6061/clinics/2021/e2350. eCollection 2021.
To investigate predictors and propose reference equations for the augmentation index normalized to 75 bpm heart rate (AIx@75) in healthy children and adolescents.
This was a cross-sectional, observational study involving 134 healthy children and adolescents aged 9 to 19 years old. Participants were categorized into child (n=53) and adolescent (n=81) groups, as well as into male (n=69) and female (n=65) groups. We evaluated AIx@75, vascular and hemodynamic parameters, anthropometric data, physical activity profile, and quality of life (Peds-QL4.0; physical, emotional, social and school domains).
The predictors of AIx@75 in the whole sample were age, peripheral diastolic blood pressure (pDBP), mean arterial pressure, pulse pressure amplification (PPA), systolic volume (SV), cardiac index (CI), and pulse wave velocity (PWV; R2=80.47%). In the male group, the predictors of AIx@75 were SV, CI, total vascular resistence (TVR), and PWV (R2=78.56%), while in the female group, they were pDBP, PPA, SV, and PWV (R2=82.45%). In the children, they were pDBP, PPA, SV, and PWV (R2=79.17%), while in the adolescents, they were body mass index, pDBP, PPA, SV, TVR, and PWV (R2=81.57%).
In the present study, we used a representative sample from Belo Horizonte to establish normality values of AIx@75. We also identified, for the first time, independent predictors of AIx@75 in healthy children and adolescents categorized by sex and age. Determining AIx@75 reference equations may facilitate the early diagnosis of preclinical atherosclerosis and allow an objective measure of the vascular effects of therapeutic interventions aimed at modifying cardiovascular risk factors.
探讨健康儿童和青少年心率归一化到 75 次/分的增强指数（AIx@75）的预测因素，并提出参考方程。
这是一项横断面、观察性研究，纳入了 134 名年龄在 9 至 19 岁的健康儿童和青少年。参与者分为儿童（n=53）和青少年（n=81）组，以及男性（n=69）和女性（n=65）组。我们评估了 AIx@75、血管和血流动力学参数、人体测量数据、体力活动水平和生活质量（Peds-QL4.0；身体、情感、社会和学校领域）。
全样本中 AIx@75 的预测因素为年龄、外周舒张压（pDBP）、平均动脉压、脉压放大率（PPA）、收缩容积（SV）、心指数（CI）和脉搏波速度（PWV；R2=80.47%）。男性组 AIx@75 的预测因素为 SV、CI、总血管阻力（TVR）和 PWV（R2=78.56%），而女性组为 pDBP、PPA、SV 和 PWV（R2=82.45%）。儿童组的预测因素为 pDBP、PPA、SV 和 PWV（R2=79.17%），而青少年组为体重指数、pDBP、PPA、SV、TVR 和 PWV（R2=81.57%）。
本研究使用来自贝洛奥里藏特的代表性样本建立了 AIx@75 的正常参考值。我们还首次确定了按性别和年龄分类的健康儿童和青少年 AIx@75 的独立预测因素。确定 AIx@75 的参考方程可能有助于早期诊断临床前动脉粥样硬化，并为评估旨在改变心血管危险因素的治疗干预的血管效应提供客观指标。
