Institute of Clinical Medicine, University of Tartu, 50406, Tartu, Estonia.
Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia.
Arch Osteoporos. 2023 May 3;18(1):62. doi: 10.1007/s11657-023-01257-3.
Longitudinal bone content data from puberty to adulthood was assessed in 102 healthy males and associations with arterial health in adulthood was analysed. Bone growth in puberty was related to arterial stiffening and final bone mineral content to decreased arterial stiffness. Relationships with arterial stiffness were dependent on the studied bone regions.
Our aim was to assess the relationships between arterial parameters in adulthood and bone parameters in several locations longitudinally from puberty to 18-years and cross-sectionally at 18-years.
102 healthy male data from a 7-year follow-up study was used to analyse total body (TB), femoral neck (FN) and lumbar spine (LS) mineral content and density by DXA, carotid intima-media thickness (cIMT) by ultrasound, carotid-femoral pulse wave velocity (cfPWV) and heart rate adjusted augmentation index (AIxHR75) by applanation tonometry.
Linear regression analysis revealed negative associations between LS bone mineral density (BMD) and cfPWV [ß=-1.861, CI -3.589, -0.132, p=0.035] which remained significant [ß=-2.679, CI -4.837, -0.522, p=0.016] after adjustment to smoking, lean mass, weight category, pubertal stage, physical fitness, and activity. For AIxHR75 similar results were present [ß=-0.286, CI -0.553, -0.020, p=0.035], but were dependent on confounders. Analysis on pubertal bone growth speed showed independent positive associations to AIxHR75 between Δ FN bone mineral apparent density (BMAD) [ß=672.50, CI 348.07, 996.93, p<0.001] and Δ LS BMAD [ß=700.40, CI 57.384, 1343.423, p=0.033]. Further analysis combining pubertal bone growth and adulthood BMC revealed that the relationships of AIxHR75 with LS BMC and ΔFN BMAD were independent of each other.
Trabecular bone regions like lumbar spine and femoral neck, showed stronger relationships with arterial stiffness. Rapid bone growth in puberty is related to arterial stiffening, while final bone mineral content relates to decreased arterial stiffness. These results could indicate that bone metabolism is independently associated with arterial stiffness rather than bone and arteries just having common traits of growth and maturation.
评估青春期至成年期的纵向骨含量数据，并分析其与成年期动脉健康的关系。研究发现，青春期的骨骼生长与动脉僵硬有关，最终的骨矿物质含量与动脉僵硬程度降低有关。与动脉僵硬的关系取决于所研究的骨骼区域。
使用一项为期 7 年的随访研究中的 102 名健康男性数据，通过 DXA 分析全身（TB）、股骨颈（FN）和腰椎（LS）的矿物质含量和密度，通过超声测量颈动脉内膜中层厚度（cIMT），通过平板张力测量颈动脉-股动脉脉搏波速度（cfPWV）和心率校正的增强指数（AIxHR75）。
线性回归分析显示，LS 骨密度（BMD）与 cfPWV 呈负相关[β=-1.861，CI-3.589，-0.132，p=0.035]，调整吸烟、瘦体重、体重类别、青春期阶段、体能和活动后，该相关性仍具有统计学意义[β=-2.679，CI-4.837，-0.522，p=0.016]。对于 AIxHR75，也存在类似的结果[β=-0.286，CI-0.553，-0.020，p=0.035]，但取决于混杂因素。对青春期骨生长速度的分析显示，Δ FN 骨矿物质表观密度（BMAD）[β=672.50，CI 348.07，996.93，p<0.001]和Δ LS BMAD[β=700.40，CI 57.384，1343.423，p=0.033]与 AIxHR75 之间存在独立的正相关。进一步分析结合青春期骨生长和成年 BMC 发现，LS BMC 和 ΔFN BMAD 与 AIxHR75 的关系是相互独立的。
松质骨区域，如腰椎和股骨颈，与动脉僵硬的关系更强。青春期骨骼生长迅速与动脉僵硬有关，而最终的骨矿物质含量与动脉僵硬程度降低有关。这些结果表明，骨代谢与动脉僵硬独立相关，而不是骨骼和动脉仅仅具有生长和成熟的共同特征。
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