PhD, Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, People's Liberation Army Medical College, Beijing, China.
Master, Department of Respiratory Medicine, Tangshan Central Hospital, Tangshan, China.
Acta Cir Bras. 2021 Jan 20;35(12):e351206. doi: 10.1590/ACB351206. eCollection 2021.
To investigate the protective effect of L-carnitine on myocardial injury in rats with heatstroke.
orty-eight rats were randomly divided into control, heatstroke and 25, 50 and 100 mg/kg L-carnitine groups. The last three groups were treated with 25, 50 and 100 mg/kg L-carnitine, respectively, for seven successive days. Then, except for the control group, the other four groups were transferred into the environment with ambient temperature of (39.5 ± 0.4 °C) and relative humidity of (13.5 ± 2.1%) for 2 h. The core temperature (Tc), mean arterial pressure (MAP), heart rate (HR) and serum and myocardial indexes were detected.
Compared with the heatstroke group, in the 100 mg/kg L-carnitine group, the Tc was significantly decreased, the MAP and HR were significantly increased, the serum creatine kinase, lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, tumor necrosis factor α and interleukin 1β levels were significantly decreased, the myocardial superoxide dismutase and glutathione peroxidase levels were significantly increased, the myocardial malondialdehyde level was significantly decreased and the cardiomyocyte apoptosis index and myocardial caspase-3 protein expression level were remarkably decreased (p < 0.05).
The L-carnitine pretreatment can alleviate the myocardial injury in heatstroke rats through reducing the inflammatory response, oxidative stress and cardiomyocyte apoptosis.
探讨左旋肉碱对热射病大鼠心肌损伤的保护作用。
48 只大鼠随机分为对照组、热射病组和 25、50、100mg/kg 左旋肉碱组。后三组分别给予 25、50、100mg/kg 左旋肉碱，连续 7 天。然后，除对照组外，其余四组大鼠转移至环境温度（39.5±0.4）℃、相对湿度（13.5±2.1）%的环境中 2h。检测大鼠的核心温度（Tc）、平均动脉压（MAP）、心率（HR）和血清及心肌指标。
与热射病组相比，100mg/kg 左旋肉碱组 Tc 明显降低，MAP 和 HR 明显升高，血清肌酸激酶、乳酸脱氢酶、碱性磷酸酶、天门冬氨酸氨基转移酶、肿瘤坏死因子α和白细胞介素 1β水平明显降低，心肌超氧化物歧化酶和谷胱甘肽过氧化物酶水平明显升高，心肌丙二醛水平明显降低，心肌细胞凋亡指数和心肌 caspase-3 蛋白表达水平显著降低（p<0.05）。
左旋肉碱预处理可通过减轻炎症反应、氧化应激和心肌细胞凋亡来减轻热射病大鼠的心肌损伤。
