Phytomedicine Research Center, Department of Botany, University of Fort Hare, Alice 5700, South Africa.
Food Chem Toxicol. 2010 Jul;48(7):1969-72. doi: 10.1016/j.fct.2010.04.046. Epub 2010 May 6.
Artemisiaafra Jacq. ex Willd. is a widely used medicinal plant in South Africa for the treatment of various diseases. In this study, the effect of the herb on isoproterenol (ISO)-induced myocardial injury in rats was investigated. Pretreatment with the aqueous leaf extract of the plant at 100 and 200 mg/kg body weight for 30 days prevented the elevation of serum marker enzymes namely lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) in myocardial injured rats. ISO-induced animals exhibited decreased levels of glutathione reductase (GR), glutathione peroxides (GPx), superoxide dismutase (SOD) and glutathione (GSH) in the heart, which were restored to near normal levels following treatment with the herb. The extract also attenuated lipid peroxidation (LPO) in the heart and improved the imbalance in lipid profile caused by ISO. The effect was more prominent at 200 mg/kg body weight. These findings revealed the cardioprotective effect of A. afra against isoproterenol-induced myocardial injury.
Artemisiaafra Jacq. ex Willd. 是南非广泛使用的药用植物，用于治疗各种疾病。在这项研究中，研究了该草药对异丙肾上腺素 (ISO) 诱导的大鼠心肌损伤的影响。该植物的水提叶提取物以 100 和 200mg/kg 体重预处理 30 天，可防止心肌损伤大鼠血清标志物酶即乳酸脱氢酶 (LDH)、天冬氨酸转氨酶 (AST)、丙氨酸转氨酶 (ALT) 和碱性磷酸酶 (ALP) 的升高。ISO 诱导的动物表现出心脏中谷胱甘肽还原酶 (GR)、谷胱甘肽过氧化物酶 (GPx)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH) 水平降低，用该草药治疗后接近正常水平。该提取物还可减轻心脏中的脂质过氧化 (LPO) 并改善 ISO 引起的脂质谱失衡。在 200mg/kg 体重时效果更为明显。这些发现揭示了 A. afra 对异丙肾上腺素诱导的心肌损伤的心脏保护作用。
