Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA; email:
Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.
Annu Rev Biophys. 2021 May 6;50:135-156. doi: 10.1146/annurev-biophys-062920-063704. Epub 2021 Jan 27.
This review deals with two important concepts-protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder-based biological liquid-liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.
这篇综述涉及两个重要概念——蛋白质固有无序和蛋白质无膜细胞器（PMLO）。在过去的 20 年中，科学界对这两个现象产生了浓厚的兴趣。然而，这些现象并非本世纪的新发现，而是长期以来被科学界忽视的旧观点的适时再现。以固有无序为基础的生物液-液相分离的形式将这些概念融合在一起，为理解 PMLO 生物发生的分子机制提供了基础。
