Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Cell Rep. 2021 Jan 26;34(4):108668. doi: 10.1016/j.celrep.2020.108668.
Some of the most enduring social connections begin when infants first recognize their caregivers, memories that form the basis of many family relationships. It remains unknown whether these early social memories persist into adulthood in mice and, if so, which brain regions support them. Here we show that mice form memories of their mother within days after birth and that these memories persist into adulthood. Pups display greater interest in the mother than in an unfamiliar dam before weaning, after which this preference reverses. Inhibition of CA2 neurons in the pup temporarily blocks the ability to discriminate between the mother and an unfamiliar dam, whereas doing so in adulthood prevents the formation of short-term memories about conspecifics, as well as social discrimination related to long-term memories of the mother. These results suggest that the CA2 supports memories of the mother during infancy and adulthood with a developmental switch in social preference.
一些最持久的社会关系始于婴儿最初识别照顾者的时候，这些记忆构成了许多家庭关系的基础。目前还不清楚这些早期的社会记忆是否会在成年后在老鼠身上持续存在，如果存在，哪些大脑区域支持它们。在这里，我们发现老鼠在出生后几天内就会形成对母亲的记忆，而且这些记忆会持续到成年。在断奶之前，幼崽对母亲的兴趣比对陌生的母鼠更大，之后这种偏好就会反转。在幼崽中抑制 CA2 神经元会暂时阻止它们区分母亲和陌生的母鼠，而在成年后这样做会阻止形成关于同种个体的短期记忆，以及与对母亲的长期记忆相关的社会辨别。这些结果表明，CA2 在婴儿期和成年期都支持对母亲的记忆，并且在社会偏好上存在发育性转变。
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