Cilz Nicholas I, Cymerblit-Sabba Adi, Young W Scott
Section on Neural Gene Expression, National Institute of Mental Health, Bethesda, Maryland.
Genes Brain Behav. 2019 Jan;18(1):e12535. doi: 10.1111/gbb.12535. Epub 2018 Dec 10.
The role of the hippocampus in social memory and behavior is under intense investigation. Oxytocin (Oxt) and vasopressin (Avp) are two neuropeptides with many central actions related to social cognition. Oxt- and Avp-expressing fibers are abundant in the hippocampus and receptors for both peptides are seen throughout the different subfields, suggesting that Oxt and Avp modulate hippocampal-dependent processes. In this review, we first focus on the anatomical sources of Oxt and Avp input to the hippocampus and consider the distribution of their corresponding receptors in different hippocampal subfields and neuronal populations. We next discuss the behavioral outcomes related to social memory seen with perturbation of hippocampal Oxt and Avp signaling. Finally, we review Oxt and Avp modulatory mechanisms in the hippocampus that may underlie the behavioral roles for both peptides.
海马体在社会记忆和行为中的作用正受到深入研究。催产素（Oxt）和加压素（Avp）是两种神经肽，具有许多与社会认知相关的中枢作用。表达Oxt和Avp的纤维在海马体中丰富，且两种肽的受体在不同亚区均可见，这表明Oxt和Avp调节依赖海马体的过程。在本综述中，我们首先关注输入到海马体的Oxt和Avp的解剖学来源，并考虑它们相应受体在不同海马亚区和神经元群体中的分布。接下来，我们讨论海马体Oxt和Avp信号传导受到干扰时与社会记忆相关的行为结果。最后，我们综述海马体中Oxt和Avp的调节机制，这可能是两种肽发挥行为作用的基础。
