振动光谱学在生物医学中的应用：口腔癌诊断。

Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics.

机构信息

FOCAS Research Institute, Technological University Dublin, City Campus, Dublin 8, Ireland.

School of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland; Radiation and Environmental Science Centre, FOCAS Research Institute, Technological University Dublin, City Campus, Dublin 8, Ireland.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2021 May 5;252:119470. doi: 10.1016/j.saa.2021.119470. Epub 2021 Jan 23.

DOI:10.1016/j.saa.2021.119470

PMID:33503511

Abstract

Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.

摘要

振动光谱学，基于红外吸收或拉曼散射，已经引起了人们对生物医学应用的越来越多的关注。本文回顾了用于诊断口腔潜在恶性疾病和癌症的概念验证探索，并对最近的进展进行了批判性评估。为了说明问题，还展示了拉曼显微光谱学在组织学、细胞学和唾液样本分析中的应用的具体实例，并讨论了最终用于常规、椅旁体内筛查的未来前景。