COVID-19 感染对孕妇细胞因子谱的影响：一项前瞻性病例对照研究。
The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study.
机构信息
Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Ankara University, Faculty of Medicine, Internal Medicine, Pathophysiology Department, Ankara University, Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara, Turkey.
出版信息
Cytokine. 2021 Apr;140:155431. doi: 10.1016/j.cyto.2021.155431. Epub 2021 Jan 15.
OBJECTIVE
To compare the levels of various cytokines between pregnant women with confirmed coronavirus disease (COVID-19) infection and pregnant women without any defined risk factor.
MATERIALS AND METHODS
Pregnant women with confirmed COVID-19 infection (study group)(n = 90) were prospectively compared to a gestational age-matched control group of pregnant women without any defined risk factors (n = 90). Demographic features, clinical characteristics, laboratory parameters, interferon-gamma (IFN γ), interleukin (IL-2), IL-6, IL-10, and IL-17 levels were compared between the groups. Additionally, a correlation analysis was performed in the study group for the assessment of IFN γ, IL-2, IL-6, IL-10, and IL-17 levels with disease severity and CRP levels.
RESULTS
Study group had significantly higher pregnancy complication rate, erythrocyte sedimentation rate, C-reactive protein, procalcitonin, ferritin, D-dimer, lactate dehydrogenase, IFN γ, and IL-6 values (p < 0.05). On the other hand, the control group had significantly higher hemoglobin, leukocyte, platelet, lymphocyte, IL-2, IL-10, and IL-17 values (p < 0.05). Statistically significant differences were found between the groups for IFN γ, IL-2, IL-10, and IL-17 values between the trimesters (p < 0.05). Statistically significant positive correlations were found for IFN γ and IL-6 with disease severity (r = 0.41 and p < 0.001 for IFN γ and r = 0.58 and p < 0.001 for IL-6). On the other hand, a moderate negative correlation for IL-2 and a weak negative correlation for IL-10 were present (r = -0.62 and p < 0.001 for IL-2 and r = -0.19 and p = 0.01 for IL-10). A statistically significant positive moderate correlation was found between IL-6 and CRP (r = 0.40 and p < 0.001) CONCLUSION: COVID-19 infection seems to have an impact on the cytokine profile of pregnant women varying according to pregnancy trimesters and cytokine levels seem to be correlated with disease severity.
目的
比较确诊冠状病毒病（COVID-19）感染的孕妇与无明确危险因素的孕妇之间各种细胞因子的水平。
材料和方法
前瞻性比较 90 例确诊 COVID-19 感染的孕妇（研究组）与 90 例无任何明确危险因素的妊娠年龄匹配的对照组。比较两组的人口统计学特征、临床特征、实验室参数、干扰素-γ（IFN γ）、白细胞介素（IL-2）、IL-6、IL-10 和 IL-17 水平。此外，在研究组中进行了相关性分析，以评估 IFN γ、IL-2、IL-6、IL-10 和 IL-17 水平与疾病严重程度和 CRP 水平的相关性。
结果
研究组的妊娠并发症发生率、红细胞沉降率、C 反应蛋白、降钙素原、铁蛋白、D-二聚体、乳酸脱氢酶、IFN γ 和 IL-6 值明显更高（p<0.05）。另一方面，对照组的血红蛋白、白细胞、血小板、淋巴细胞、IL-2、IL-10 和 IL-17 值明显更高（p<0.05）。IFN γ、IL-2、IL-10 和 IL-17 值在各组之间的三个孕期均存在统计学差异（p<0.05）。IFN γ 和 IL-6 与疾病严重程度呈统计学显著正相关（r=0.41 和 p<0.001 用于 IFN γ，r=0.58 和 p<0.001 用于 IL-6）。另一方面，IL-2 呈中度负相关，IL-10 呈弱负相关（r=-0.62 和 p<0.001 用于 IL-2，r=-0.19 和 p=0.01 用于 IL-10）。IL-6 和 CRP 之间存在统计学显著的正中度相关（r=0.40 和 p<0.001）。
结论
COVID-19 感染似乎对孕妇的细胞因子谱产生影响，根据妊娠 trimester 而有所不同，细胞因子水平似乎与疾病严重程度相关。
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