Perelman School of Medicine, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.
School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.
Immunity. 2020 Jul 14;53(1):19-25. doi: 10.1016/j.immuni.2020.06.017. Epub 2020 Jun 28.
The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.
与各种感染和免疫介导的情况相关的细胞因子循环水平升高通常被称为细胞因子风暴。在这里，我们解释细胞因子在“理想”反应中的保护功能；可以驱动这些反应变得病理性的多因素起源；以及这最终如何导致血管损伤、免疫病理学和临床结果恶化。
