运动和心理应激对抗炎和促炎细胞因子的影响。

The Effect of Exercise and Psychological Stress on Anti- and Proinflammatory Cytokines.

机构信息

Department of Sport Sciences, Shiraz University, Shiraz, Iran.

Department of Exercise Physiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.

出版信息

Neuroimmunomodulation. 2020;27(4):186-193. doi: 10.1159/000512814. Epub 2021 Jan 27.

DOI:10.1159/000512814

PMID:33503634

Abstract

BACKGROUND/AIMS: Research evidence regarding immune system responses and adaptations to psychological or physical stresses is controversial. This study aimed to investigate the effect of 8-week psychological stress and exercise activity (chronic adaptation) and the acute response of possibly adapted rats to psychological stress and exercise considering IFN-γ, IL-4, and IL-4/IFN-γ.

METHODS

Thirty-two rats were divided into 4 groups of 8 animals including control, exercise, psychological stress, and combination of exercise with psychological stress. IL-4 and IFN-γ cytokines were measured pre-experiment (preEX), immediately postexercise (IpostEX), and 72-h postexperiment protocol (72hpostEX).

RESULTS

There were no significant differences between the study groups regarding IFN-γ, IL-4, and IL-4/IFN-γ in preEX (p > 0.05), IpostEX (p > 0.05), and 72hpostEX (p > 0.05). However, IL-4 increased significantly in IpostEX compared with preEX in exercise (p = 0.012) and combination of exercise with psychological stress (p = 0.03) groups.

CONCLUSIONS

Exercise and combination of exercise and psychological stress induce similar acute response to IL-4 in chronic trained and stressed rats. Also, exercise may induce an acute synergistic effect with psychological stress on IL-4.

摘要

背景/目的：关于免疫系统对心理或生理压力的反应和适应的研究证据存在争议。本研究旨在探讨 8 周心理压力和运动活动（慢性适应）以及可能适应压力的大鼠对心理压力和运动的急性反应对 IFN-γ、IL-4 和 IL-4/IFN-γ 的影响。

方法

32 只大鼠分为 4 组，每组 8 只，包括对照组、运动组、心理应激组和运动与心理应激联合组。在实验前（preEX）、运动后即刻（IpostEX）和实验后 72 小时方案（72hpostEX）测量 IL-4 和 IFN-γ 细胞因子。

结果

在 preEX（p>0.05）、IpostEX（p>0.05）和 72hpostEX（p>0.05）时，各组间 IFN-γ、IL-4 和 IL-4/IFN-γ 无显著差异。然而，运动组和运动与心理应激联合组的 IpostEX 中 IL-4 与 preEX 相比显著增加（p=0.012 和 p=0.03）。