Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland.
FREEZE-Biobank, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Breisacherstr. 115 4, D-79106 Freiburg, Germany.
Nutrients. 2021 Jan 25;13(2):360. doi: 10.3390/nu13020360.
We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.
我们旨在评估孕妇妊娠早期（第 1 孕期）和分娩前几天（第 3 孕期）的甲状旁腺激素（PTH）浓度，并评估其决定因素。在 2014 年 9 月至 2015 年 12 月的一项横断面研究中，招募了 204 名妊娠第 1 孕期的妇女和 203 名妊娠第 3 孕期的妇女。采集血样以测量 PTH 和循环 25-羟维生素 D（25（OH）D）浓度。使用问卷收集生活方式和人口统计学数据。在早期和晚期妊娠中，血清 25（OH）D 和 PTH 呈负相关。我们的分析表明，在妊娠晚期，25（OH）D 水平为 18.9ng/ml（47.3nmol/L）可能是 PTH 最大抑制的拐点。在多元回归中，25（OH）D 浓度、季节、多产和伴侣的教育（均<0.05）是妊娠早期 PTH 浓度的统计学显著决定因素。在妊娠晚期，25（OH）D 浓度和原籍国是 PTH 浓度的统计学显著决定因素（均<0.05）。这些因素及其对 PTH 的影响似乎主要由 25（OH）D 决定；然而，它们也可能通过除 25（OH）D 以外的其他机制影响 PTH。
