Skaaby Tea, Husemoen Lise Lotte Nystrup, Thuesen Betina Heinsbæk, Pisinger Charlotta, Hannemann Anke, Jørgensen Torben, Linneberg Allan
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Endocrine. 2016 Feb;51(2):342-50. doi: 10.1007/s12020-015-0641-7. Epub 2015 May 30.
Several lifestyle factors have been found to be associated with vitamin D status in cross-sectional studies, but it is not clear whether a change in these factors can actually affect the vitamin D level. We investigated the association between repeated measurements of physical activity, body mass index (BMI), diet, alcohol consumption, and smoking habits, and corresponding levels of vitamin D during 5 years of follow-up of a large general population sample. We included 4185 persons who participated and had vitamin D (serum-25-hydroxyvitamin D, 25-OH-D) measurements in the Inter99 study at baseline (1999-2001) and 5-year follow-up. In a subsample, 25-OH-D was also measured at 1- and 3-year follow-ups. We used mixed models to examine the association between repeated measurements of lifestyle factors and 25-OH-D levels. In multivariable analyses of repeated measurements, the difference in 25-OH-D was -0.32 ng/ml (95 % CI -0.37, -0.28) per 1 kg/m(2) increase in BMI; 4.50 ng/ml (95 % CI 3.84, 5.15) for persons moderately/vigorously physically active versus sedentary; 1.82 ng/ml (95 % CI 1.09, 2.56) for persons with healthy versus unhealthy dietary habits; 0.05 ng/ml (95 % CI 0.03, 0.07) per 1 standard drink/weak increase in alcohol consumption; and 0.86 ng/ml (95 % CI 0.36, 1.35) for never smokers versus daily smokers. Our study shows that lower BMI, a higher level of physical activity, a healthier diet and possibly a higher alcohol intake, and not smoking, are associated with higher 25-OH-D levels.
在横断面研究中，已发现多种生活方式因素与维生素D水平相关，但尚不清楚这些因素的改变是否真的会影响维生素D水平。我们在一个大型普通人群样本的5年随访期间，调查了身体活动量、体重指数（BMI）、饮食、酒精摄入量和吸烟习惯的重复测量值与相应维生素D水平之间的关联。我们纳入了4185名在基线期（1999 - 2001年）和5年随访期参与Inter99研究并进行了维生素D（血清25 - 羟基维生素D，25 - OH - D）测量的人员。在一个子样本中，还在1年和3年随访期测量了25 - OH - D。我们使用混合模型来检验生活方式因素的重复测量值与25 - OH - D水平之间的关联。在重复测量的多变量分析中，BMI每增加每1kg/m²，25 - OH - D的差异为 - 0.32ng/ml（95%CI - 0.37， - 0.28）；中度/剧烈身体活动者与久坐者相比，差异为4.50ng/ml（95%CI 3.84，5.15）；饮食习惯健康者与不健康者相比，差异为1.82ng/ml（95%CI 1.09，2.56）；酒精摄入量每增加每1标准杯/周，差异为0.05ng/ml（95%CI 0.03，0.07）；从不吸烟者与每日吸烟者相比，差异为0.86ng/ml（95%CI 0.36，1.35）。我们的研究表明，较低的BMI、较高的身体活动水平、更健康的饮食以及可能较高的酒精摄入量，且不吸烟，与较高的25 - OH - D水平相关。
