对“我们所有人”研究计划数据库进行评估，以检查累积压力。
An evaluation of the All of Us Research Program database to examine cumulative stress.
作者信息
Beese Shawna, Abshire Demetrius A, DeJong Trey L, Carbone Jason T
机构信息
College of Agricultural, Human, and Natural Resources Sciences, Extension, Washington State University, Pullman, WA 99164, United States.
Department of Nursing and Systems Science, College of Nursing, Washington State University, Spokane, WA 99202, United States.
出版信息
J Am Med Inform Assoc. 2024 Dec 1;31(12):2968-2973. doi: 10.1093/jamia/ocae201.
OBJECTIVES
To evaluate the NIH All of Us Research Program database as a potential data source for studying allostatic load and stress among adults in the United States (US).
MATERIALS AND METHODS
We evaluated the All of Us database to determine sample size significance for original-10 allostatic load biomarkers, Allostatic Load Index-5 (ALI-5), Allostatic Load Five, and Cohen's Perceived Stress Scale (PSS). We conducted a priori, post hoc, and sensitivity power analyses to determine sample sizes for conducting null hypothesis significance tests.
RESULTS
The maximum number of responses available for each measure is 21 participants for the original-10 allostatic load biomarkers, 150 for the ALI-5, 22 476 for Allostatic Load Five, and n = 90 583 for the PSS.
DISCUSSION
The NIH All of Us Research Program is well-suited for studying allostatic load using the Allostatic Load Five and psychological stress using PSS.
CONCLUSION
Improving biomarker data collection in All of Us will facilitate more nuanced examinations of allostatic load among US adults.
目的
评估美国国立卫生研究院（NIH）的“我们所有人”研究计划数据库，作为研究美国成年人的应激负荷和压力的潜在数据源。
材料与方法
我们评估了“我们所有人”数据库，以确定针对原始的10种应激负荷生物标志物、应激负荷指数-5（ALI-5）、应激负荷五项指标以及科恩感知压力量表（PSS）的样本量显著性。我们进行了先验、事后和敏感性功效分析，以确定进行零假设显著性检验所需的样本量。
结果
每种测量方法可获得的最大应答数分别为：原始的10种应激负荷生物标志物有21名参与者，ALI-5有150名，应激负荷五项指标有22476名，PSS有n = 90583名。
讨论
NIH的“我们所有人”研究计划非常适合使用应激负荷五项指标研究应激负荷，并使用PSS研究心理压力。
结论
改进“我们所有人”数据库中的生物标志物数据收集工作，将有助于更细致地研究美国成年人的应激负荷。
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