Division of Infectious Disease Therapeutics, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Division of Infectious Disease Therapeutics, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
BMJ Case Rep. 2021 Jan 27;14(1):e237894. doi: 10.1136/bcr-2020-237894.
Both the inactivated hepatitis A vaccine (Aimmugen) and purified chick embryo cell rabies vaccine (PCECV, Rabipur) are well tolerated. Anaphylaxis has rarely been reported as an adverse reaction of these vaccines. There have been no reports or published case reports of anaphylaxis due to Aimmugen. According to the Japanese Ministry of Health, Labour and Welfare Aimmugen adverse reaction report, no cases of anaphylaxis have been reported from April 2013 to August 2016. Twenty cases of anaphylaxis due to PCECV (RabAvert) have been reported from 1997 to 2005 in USA, whereas 2 cases have been reported from 2006 to 2016. We report a case of anaphylaxis after multiple vaccinations in a 24-year-old man with ulcerative colitis, previous medical history of tonsillectomy for IgA nephropathy and no history of allergies.
甲型肝炎灭活疫苗（Aimmugen）和纯化鸡胚细胞狂犬病疫苗（PCECV，Rabipur）均具有良好的耐受性。过敏反应很少作为这些疫苗的不良反应报告。目前尚无因 Aimmugen 引起过敏反应的报告或已发表的病例报告。根据日本厚生劳动省 Aimmugen 不良反应报告，2013 年 4 月至 2016 年 8 月未报告过敏反应病例。1997 年至 2005 年，美国报告了 20 例因 PCECV（RabAvert）引起的过敏反应病例，而 2006 年至 2016 年报告了 2 例。我们报告了一例溃疡性结肠炎 24 岁男性患者多次接种疫苗后发生过敏反应的病例，该患者既往有扁桃体切除术治疗 IgA 肾病病史，无过敏史。
