Brien Holden Institute of Optometry and Vision Sciences, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Sci Rep. 2021 Jan 27;11(1):2285. doi: 10.1038/s41598-021-81530-y.
To evaluate the changes in functional vision in patients with resolved endophthalmitis. This was a cross-sectional study. The study included 20 patients with resolved endophthalmitis and best-corrected visual acuity of 20/100 or better. Visual acuity (VA), contrast threshold (CT), red/green (RG) and yellow/blue (YB) colour vision and 15 Hz flicker modulation threshold (FMT) were assessed using standard psychophysical techniques. The median age was 54 years. The median visual acuity was 0.27 (~ 20/40-Snellen Equivalent) ((interquartile range [IQR]), 0.30) logMAR). The median log contrast threshold (CT) was - 1.13 (IQR, 0.36) log units (normative value for age-matched CT: - 1.61 log units). The median red/green (RG) and yellow/blue (YB) thresholds were 11.52 (IQR, 26.19) and 9.45 (IQR, 16.20) CAD units respectively, which were at least 5 times higher than age-matched normative RG and YB thresholds. The median central cone- mediated FMT was 17.64% (IQR, 23.40%), which was much higher compared to age-matched FMT (5.48% [IQR, 3.47]). Linear regression revealed significant relationship between contrast thresholds and foveal thickness (y = 0.001x-1.47, R = 0.20, p = 0.048). Though endophthalmitis may resolve with a good visual acuity, deficits in visual functions like chromatic discrimination, cone-mediated flicker and contrast sensitivity persist.
评估已解决眼内炎患者的功能视力变化。这是一项横断面研究。研究纳入 20 名已解决眼内炎且最佳矫正视力≥20/100 的患者。采用标准心理物理学技术评估视力（VA）、对比阈值（CT）、红/绿（RG）和黄/蓝（YB）色觉以及 15 Hz 闪烁调制阈值（FMT）。中位年龄为 54 岁。中位视力为 0.27（~20/40-斯耐伦等效视力）（四分位距[IQR]，0.30）logMAR。中位 log 对比阈值（CT）为-1.13（IQR，0.36）log 单位（年龄匹配 CT 的正常值为-1.61 log 单位）。中位红/绿（RG）和黄/蓝（YB）阈值分别为 11.52（IQR，26.19）和 9.45（IQR，16.20）CAD 单位，至少比年龄匹配 RG 和 YB 阈值高 5 倍。中位中央锥介导 FMT 为 17.64%（IQR，23.40%），与年龄匹配 FMT（5.48%[IQR，3.47%]）相比明显升高。线性回归显示 CT 与中心凹厚度之间存在显著关系（y=0.001x-1.47，R=0.20，p=0.048）。尽管眼内炎可能在视力较好的情况下得到解决，但色觉、锥介导闪烁和对比敏感度等视觉功能仍存在缺陷。
