Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, No. 280 South Chongqing Rd., Shanghai, China.
Mediators Inflamm. 2021 Jan 5;2021:6634532. doi: 10.1155/2021/6634532. eCollection 2021.
CD4 T cells play a vital role in the adaptive immune system and are involved in the pathogenesis of many diseases, including cancer, autoimmune diseases, and chronic inflammation. As an important mechanism for energy storage, a lot of researches have clarified that metabolism imbalance interacts with immune disorder, and one leads to the other. Lipid metabolism has close relationship with CD4 T cells. In this review, we discuss fatty acid, cholesterol, prostaglandin, and phospholipid metabolism in CD4 T cell subsets. Fatty acid -oxidation (FAO) is activated in Th17 cell to support the proinflammatory function. Cholesterol promotes Th1, Th2, and Treg cell differentiation. In addition to glucose metabolism, lipid metabolism is also very important for immunity. Here, it is highlighted that lipid metabolism regulates CD4 T cell differentiation and function and is related to diseases.
CD4 T 细胞在适应性免疫系统中发挥着至关重要的作用，并参与许多疾病的发病机制，包括癌症、自身免疫性疾病和慢性炎症。作为能量储存的重要机制，大量研究已经阐明代谢失衡与免疫紊乱相互作用，相互影响。脂代谢与 CD4 T 细胞密切相关。在这篇综述中，我们讨论了 CD4 T 细胞亚群中的脂肪酸、胆固醇、前列腺素和磷脂代谢。在 Th17 细胞中，脂肪酸氧化（FAO）被激活以支持其促炎功能。胆固醇促进 Th1、Th2 和 Treg 细胞的分化。除了葡萄糖代谢，脂代谢对免疫也非常重要。这里强调的是，脂代谢调节 CD4 T 细胞的分化和功能，并与疾病有关。
