使用精油及其分离成分治疗口腔念珠菌病：文献综述
The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review.
作者信息
Ferreira Elba Dos Santos, Rosalen Pedro Luiz, Benso Bruna, de Cássia Orlandi Sardi Janaina, Denny Carina, Alves de Sousa Simone, Queiroga Sarmento Guerra Felipe, de Oliveira Lima Edeltrudes, Almeida Freires Irlan, Dias de Castro Ricardo
机构信息
Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil.
Federal University of Alfenas, Alfenas, MG, Brazil.
出版信息
Evid Based Complement Alternat Med. 2021 Jan 7;2021:1059274. doi: 10.1155/2021/1059274. eCollection 2021.
In this literature review, we present the main scientific findings on the antifungal activity of essential oils (EOs) applicable for a new drug formulation to treat oral candidiasis. Seven literature databases were systematically searched for eligible in vitro and clinical trials. Selected articles were screened for biological activity, botanical species, phytochemical composition, study design, and methodological quality. A total of 26 articles were included in the review, of which 21 were in vitro studies and 5 clinical trials. The most promising EOs were obtained from , , , and L. Among the phytochemicals, citral and thymol were the most active. Clinical trials indicated that the EOs from and are potentially effective to treat oral candidiasis. Further nonclinical and clinical studies with these EO are warranted to determine their potential use and safety for the treatment of oral candidiasis.
在本综述中，我们介绍了适用于治疗口腔念珠菌病的新药制剂的精油（EOs）抗真菌活性的主要科学发现。系统检索了七个文献数据库以查找符合条件的体外和临床试验。对所选文章进行了生物活性、植物种类、植物化学成分、研究设计和方法学质量的筛选。本综述共纳入26篇文章，其中21篇为体外研究，5篇为临床试验。最有前景的精油来自[此处原文缺失具体植物名称]、[此处原文缺失具体植物名称]、[此处原文缺失具体植物名称]和罗勒属植物。在植物化学物质中，柠檬醛和百里香酚活性最强。临床试验表明，[此处原文缺失具体植物名称]和[此处原文缺失具体植物名称]的精油对治疗口腔念珠菌病可能有效。有必要对这些精油进行进一步的非临床和临床研究，以确定它们在治疗口腔念珠菌病方面的潜在用途和安全性。
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