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2018 年肯尼亚卡卡马和卡洛贝伊难民营霍乱的描述性横断面研究。

A descriptive cross-sectional study of cholera at Kakuma and Kalobeyei refugee camps, Kenya in 2018.

机构信息

Kenya Medical Research Institute (KEMRI) and Centres for Disease Control and Prevention (CDC), Nairobi, Kenya.

Sanofi Pasteur Vaccine Epidemiology and Modelling, Lyon, France.

出版信息

Pan Afr Med J. 2020 Oct 29;37:197. doi: 10.11604/pamj.2020.37.197.24798. eCollection 2020.

Abstract

INTRODUCTION

cholera is a significant public health concern among displaced populations. Oral cholera vaccines are safe and can effectively be used as an adjunct to prevent cholera in settings with limited access to water and sanitation. Results from this study can inform future consideration for cholera vaccination at Kakuma and Kalobeyei.

METHODS

a descriptive cross-sectional study of cholera cases at Kakuma refugee camp and Kalobeyei integrated settlement was carried out between May 2017 to May 2018 (one year). Data were extracted from the medical records and line lists at the cholera treatment centres.

RESULTS

the results found 125 clinically suspected and confirmed cholera cases and one related death (CFR 0.8%). The cumulative incidence of all cases was 0.67 (95% CI=0.56-0.80) cases/1000 persons. Incidence of cholera was higher in children under the age of five 0.94(95% CI=0.63-1.36) cases/1000 persons. Children aged <5 years showed 51% increased risk of cholera compared to those aged ≥5 years (RR=1.51; 95% CI=1.00-2.31, p=0.051). Individuals from the Democratic Republic of Congo had nearly 9-fold risk of reporting cholera (RR=8.62; 95% CI=2.55-37.11, p<0.001) while individuals from South Sudan reported 7 times risk of cholera case compared to those from Somalia (RR=7.39; 95% CI=2.78-27.73, p<0.001).

CONCLUSION

in addition to the improvement of water, sanitation and hygiene (WaSH), vaccination could be implemented as a short-medium term measure of preventing cholera outbreaks. Age, country of origin and settlement independently predicted the risk of cholera.

摘要

简介

在流离失所人群中,霍乱是一个重大的公共卫生关切问题。口服霍乱疫苗安全有效,可在供水和环境卫生条件有限的情况下,作为预防霍乱的辅助手段。本研究结果可为卡库马和卡洛贝伊未来考虑接种霍乱疫苗提供信息。

方法

2017 年 5 月至 2018 年 5 月(1 年)期间,对卡库马难民营和卡洛贝伊综合定居点的霍乱病例进行了描述性横断面研究。数据从霍乱治疗中心的病历和列表中提取。

结果

共发现 125 例临床疑似和确诊霍乱病例,1 例相关死亡(病死率 0.8%)。所有病例的累积发病率为 0.67(95%CI=0.56-0.80)例/1000 人。5 岁以下儿童的霍乱发病率较高,为 0.94(95%CI=0.63-1.36)例/1000 人。与 5 岁及以上人群相比,年龄<5 岁的儿童患霍乱的风险增加 51%(RR=1.51;95%CI=1.00-2.31,p=0.051)。来自刚果民主共和国的人报告霍乱的风险几乎增加了 9 倍(RR=8.62;95%CI=2.55-37.11,p<0.001),而来自南苏丹的人报告霍乱的风险是来自索马里的人的 7 倍(RR=7.39;95%CI=2.78-27.73,p<0.001)。

结论

除了改善水、环境卫生和个人卫生(WASH)之外,接种疫苗可以作为预防霍乱暴发的短期至中期措施。年龄、原籍国和定居点独立预测了霍乱的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae7b/7813661/b7c6b4af1fd6/PAMJ-37-197-g001.jpg

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