Olagunju Aderonke Ibidunni, Oluwajuyitan Timilehin David, Oyeleye Sunday Idowu
Department of Food Science and Technology, Federal University of Technology, Akure 34002, Nigeria.
Department of Biomedical Technology, Federal University of Technology, Akure 34002, Nigeria.
Prev Nutr Food Sci. 2020 Dec 31;25(4):362-374. doi: 10.3746/pnf.2020.25.4.362.
The pharmacological properties of various parts of plantain trees have directed its use in folkloric management of diabetes and other human ailments. However, little is known about plantain bulb extract (PBE) and their mechanisms of action. This study evaluated the effect of PBE-beverage blends (including 1% and 2 % cocoa powder) sweetened with honey on blood glucose levels, antioxidant status, and carbohydrate hydrolysing enzyme activities in streptozotocin (STZ)-induced diabetic rats. Animals were selected at random and distributed into 7 groups (n=7), as follows: normal control (NC), untreated diabetic rats, diabetic rats treated with acarbose (STZ-ACA), diabetic rats administered PBE (STZ- PBE), diabetic rats administered honey and PBE (STZ-HPBE), diabetic rats administered 1% cocoa powder-with HPBE blend (STZ-CHPBE-1), and diabetic rats administered 2% cocoa powder with HPBE blend (STZ-CHPBE-2). Compared with the controls, untreated diabetic rats exhibited increased blood glucose levels and hydrolysing enzyme activities, and significant decreases in the activities of antioxidant (catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase) enzyme and non-enzymatic (glutathione) antioxidants. However, changes in activities were comparatively reversed in all rats administered plantain bulb formulations. CHPBE-2 was slightly more effective than CHPBE-1. Overall, both blends could serve as nutraceutical and/or functional drinks in the management of diabetes.
芭蕉树各部分的药理特性使其在民间用于糖尿病及其他人类疾病的治疗。然而，人们对芭蕉球茎提取物（PBE）及其作用机制知之甚少。本研究评估了用蜂蜜调味的PBE饮料混合物（包括1%和2%的可可粉）对链脲佐菌素（STZ）诱导的糖尿病大鼠血糖水平、抗氧化状态和碳水化合物水解酶活性的影响。动物被随机选取并分为7组（n = 7），如下：正常对照组（NC）、未治疗的糖尿病大鼠、用阿卡波糖治疗的糖尿病大鼠（STZ - ACA）、给予PBE的糖尿病大鼠（STZ - PBE）、给予蜂蜜和PBE的糖尿病大鼠（STZ - HPBE）、给予1%可可粉与HPBE混合物的糖尿病大鼠（STZ - CHPBE - 1）以及给予2%可可粉与HPBE混合物的糖尿病大鼠（STZ - CHPBE - 2）。与对照组相比，未治疗的糖尿病大鼠血糖水平和水解酶活性升高，抗氧化（过氧化氢酶、超氧化物歧化酶、谷胱甘肽 - S - 转移酶和谷胱甘肽过氧化物酶）酶和非酶（谷胱甘肽）抗氧化剂的活性显著降低。然而，在所有给予芭蕉球茎制剂的大鼠中，活性变化相对逆转。CHPBE - 2比CHPBE - 1稍有效。总体而言，两种混合物都可作为糖尿病管理中的营养保健品和/或功能性饮料。
