Department of Food Science and Technology, Federal University of Technology, Akure, Nigeria.
Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
J Food Biochem. 2021 Mar;45(3):e13334. doi: 10.1111/jfbc.13334. Epub 2020 Jun 29.
The study evaluated the hypoglycemic effect of biscuits produced from flour blends of three medicinal foods (Unripe plantain fruits, Moringa seed, and pigeon pea) on high-fat diet (HFD)/streptozotocin (STZ)-induced (HFD/STZ) diabetic rats. The formulated biscuits were produced at different proportion of the flour blends and fed to HFD-STZ-induced diabetic rats for 14 days. The result showed that the formulated biscuits caused a significant increase in pancreas, liver, and kidney antioxidant molecules, decreased the production of thiobarbituric reactive acid species (TBARS) in pancreas, liver, and kidney homogenates, and reduced pancreatic α-amylase and intestinal α-glucosidase activities as against untreated diabetic rats. In conclusion, the use of formulated biscuits from the blends of flours from unripe plantain, Moringa seed, and pigeon pea could serve as functional food toward the treatment/management of diabetes and its possible complications such as diabetes-induced liver and kidney damage. PRACTICAL APPLICATIONS: The drug use in the management of diabetes such as acarbose have been reported to have side effects, while diet therapy is gaining much interest in the management of diabetes. Hence, there is a need for diets base therapy that will not only cure diabetes, but also combat its complications. In sight of this, unripe plantain, Moringa seed, and pigeon pea flours were blended and used to produce functional biscuits for diabetic rats. The biscuit could be produced on the large scale under hygienic and regulated condition.
该研究评估了由三种药用食品（未成熟的芭蕉果实、辣木籽和兵豆）的面粉混合物制成的饼干对高脂肪饮食（HFD）/链脲佐菌素（STZ）诱导（HFD/STZ）糖尿病大鼠的降血糖作用。将配制的饼干按不同比例的面粉混合物生产，并喂食 HFD-STZ 诱导的糖尿病大鼠 14 天。结果表明，配制的饼干显著增加了胰腺、肝脏和肾脏的抗氧化分子，降低了胰腺、肝脏和肾脏匀浆中硫代巴比妥酸反应性物质（TBARS）的产生，并降低了胰腺α-淀粉酶和肠道α-葡萄糖酶的活性与未经治疗的糖尿病大鼠相比。总之，使用由未成熟芭蕉、辣木籽和兵豆的面粉混合物制成的配方饼干可以作为治疗/管理糖尿病及其可能的并发症（如糖尿病引起的肝和肾损伤）的功能性食品。实际应用：据报道，用于糖尿病管理的药物，如阿卡波糖，具有副作用，而饮食疗法在糖尿病管理中越来越受到关注。因此，需要进行基于饮食的治疗，不仅可以治愈糖尿病，还可以对抗其并发症。鉴于此，将未成熟的芭蕉、辣木籽和兵豆的面粉混合在一起，并用于生产糖尿病大鼠的功能性饼干。该饼干可以在卫生和受监管的条件下大规模生产。
