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长链非编码RNA Aerrie通过YBX1控制DNA损伤修复以维持内皮细胞功能。

Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function.

作者信息

Pham Tan Phát, Bink Diewertje I, Stanicek Laura, van Bergen Anke, van Leeuwen Esmee, Tran Yvonne, Matic Ljubica, Hedin Ulf, Wittig Ilka, Dimmeler Stefanie, Boon Reinier A

机构信息

Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.

出版信息

Front Cell Dev Biol. 2021 Jan 11;8:619079. doi: 10.3389/fcell.2020.619079. eCollection 2020.

DOI:10.3389/fcell.2020.619079
PMID:33505972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7829583/
Abstract

Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.

摘要

衰老伴随着许多生理变化。这些变化会逐渐导致多种心血管疾病。在此过程中，血管失去维持血管稳态的能力，最终导致高血压、中风或心肌梗死。DNA损伤增加是衰老的标志之一，可由DNA信号传导和修复系统修复。在我们的研究中，我们表明长链非编码RNA Aerrie（linc01013）有助于DNA信号传导和修复机制。在内皮细胞中沉默Aerrie会损害血管生成、迁移和屏障功能。Aerrie与YBX1结合，它们共同作为DNA损伤信号传导和修复的重要因子。这项研究确定Aerrie是基因组稳定性的一个新因子，也是YBX1在应对DNA损伤时的结合伙伴。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/fb9326c2869e/fcell-08-619079-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/c135ef772082/fcell-08-619079-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/fb9326c2869e/fcell-08-619079-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/c4fbe6f23ce5/fcell-08-619079-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/5fa76daf76bc/fcell-08-619079-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/42e30fec2006/fcell-08-619079-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/ade5bd9d0304/fcell-08-619079-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64b/7829583/c135ef772082/fcell-08-619079-g006.jpg
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