Department of Biosciences, Mangalore University, Mangalagangothri, 574199, India.
Division of Nutrition and Metabolism, Institute of Biomedical Science, Tokushima University, Tokushima, Japan.
Eur J Cell Biol. 2018 Apr;97(3):163-167. doi: 10.1016/j.ejcb.2018.02.003. Epub 2018 Feb 19.
YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions. Interestingly, YBX1 has been shown to localize to cytoplasmic granules such as P granules and stress granules. These granules regulate the non-coding transcriptome profile as well as mRNA translation and degradation. In this review, we discuss the recent findings on YBX1 signaling as mediated by various classes of non-coding RNAs, and on the functions of YBX1 at P granules, stress granules, exosomes, and mitochondria. YBX1 is a well-established target for cancer therapy and understanding its functions at organelles and ncRNA transcriptomes will shed new insights for devising organelle based anti-cancer therapies.
YBX1（Y 盒结合蛋白 1）是一种 RNA/DNA 结合的多功能蛋白，具有经典的冷休克蛋白（CSD）结构域、A/P 结构域和带有交替正电荷和负电荷氨基酸的长 C 端结构域。它是一种成熟的致癌转录因子，调节细胞凋亡、翻译、细胞增殖、mRNA 剪接、修复、分化和应激反应。非编码转录组为 YBX1 介导的细胞功能的主调控又增加了一层复杂性。有趣的是，YBX1 已被证明定位于细胞质颗粒，如 P 颗粒和应激颗粒。这些颗粒调节非编码转录组谱以及 mRNA 的翻译和降解。在这篇综述中，我们讨论了最近关于 YBX1 信号转导的研究结果，这些结果涉及各种类型的非编码 RNA，以及 YBX1 在 P 颗粒、应激颗粒、外泌体和线粒体中的功能。YBX1 是癌症治疗的既定靶点，了解其在细胞器和非编码转录组中的功能将为设计基于细胞器的抗癌疗法提供新的见解。
