鸡卵黄免疫球蛋白（IgY）对感染的保护作用
Protective Effects of Chicken Egg Yolk Immunoglobulins (IgYs) against Infections.
作者信息
Cai Ruizhao, Liu Ning, Guo Penghao, Liao Kang, Li Mengzhi, Zhu Junyou, Chen Shouyi, Chen Lei, Shu Bin, Qi Shaohai
机构信息
Department of Burns, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080 Guangdong Province, China.
Guangdong Engineering & Technology Research Center for Precise Diagnosis and Treatment of Burns and Wounds, Guangzhou, 510080 Guangdong Province, China.
出版信息
J Immunol Res. 2021 Jan 6;2021:6678513. doi: 10.1155/2021/6678513. eCollection 2021.
( infection is a rare disease whose death rates exceed 50% despite aggressive antibiotic treatment and surgical debridement. The aim of this study was to assess the ability of specific anti- immunoglobulins Y (IgYs) for preventing and treating infections. IgYs were produced by immunizing egg laying hens with inactivated whole cell bacteria. Peritoneal cytokines, blood's bacterial load, and survival curves were obtained from both prophylactic and therapeutic mouse models. The results showed that the specific IgYs (i) inhibited the growth of in vitro, (ii) dramatically reduced the inflammatory response and blood's bacterial load, and (iii) improved the survival rate of -infected mice. These results prove that anti- IgYs can be markedly effective means for the prophylaxis and the therapy of infections.
（感染是一种罕见疾病，尽管进行了积极的抗生素治疗和手术清创，但其死亡率仍超过50%。本研究的目的是评估特异性抗免疫球蛋白Y（IgYs）预防和治疗感染的能力。通过用灭活的全细胞细菌免疫产蛋母鸡来制备IgYs。从预防性和治疗性小鼠模型中获得腹膜细胞因子、血液中的细菌载量和生存曲线。结果表明，特异性IgYs（i）在体外抑制了的生长，（ii）显著降低了炎症反应和血液中的细菌载量，（iii）提高了感染小鼠的存活率。这些结果证明，抗IgYs可成为预防和治疗感染的显著有效手段。 ）
注
原文中部分细菌名称未完整给出，翻译时保留了英文表述。
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