Esmaeili Zahra, Kamal Shahsavar Sara, Ghazvini Kiarash
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177949025, Iran.
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad 9177949025, Iran.
Antib Ther. 2025 Mar 9;8(2):111-123. doi: 10.1093/abt/tbaf007. eCollection 2025 Apr.
The overuse of antibiotics worldwide, especially during the Coronavirus pandemic, has raised concerns about the rise of antibiotic resistance and its side effects. Immunoglobulin Y, a natural protein that specifically targets foreign antigens, holds promise as a potential therapeutic option, particularly for individuals with sensitive immune systems. Despite numerous studies on IgY, the optimal administration method, effective dose, target antigen, and potential side effects of this antibody remain areas of active research and challenge. This review selected and evaluated articles published in the last ten years from databases such as PubMed and Science Direct with appropriate keywords discussing the therapeutic effects of immunoglobulin Y in human infections . Out of all the reviewed articles, 35 articles met the inclusion criteria. The results showed that the specific antibody against dental, respiratory, and skin infections has an acceptable effectiveness. In contrast, some infections, such as neurological infections, including tetanus and botulism, still need further investigation due to the short survival time of mice. On the other hand, reporting side effects such as antibody-dependent enhancement in some infections limits its use.
全球范围内抗生素的过度使用，尤其是在新冠疫情期间，引发了人们对抗生素耐药性增加及其副作用的担忧。免疫球蛋白Y是一种专门针对外来抗原的天然蛋白质，有望成为一种潜在的治疗选择，特别是对于免疫系统敏感的个体。尽管对免疫球蛋白Y进行了大量研究，但这种抗体的最佳给药方法、有效剂量、靶抗原和潜在副作用仍是积极研究和面临挑战的领域。本综述从PubMed和ScienceDirect等数据库中选择并评估了过去十年发表的文章，这些文章使用适当的关键词讨论了免疫球蛋白Y在人类感染中的治疗效果。在所有综述文章中，有35篇符合纳入标准。结果表明，针对牙齿、呼吸道和皮肤感染的特异性抗体具有可接受的有效性。相比之下，一些感染，如包括破伤风和肉毒中毒在内的神经感染，由于小鼠存活时间短，仍需进一步研究。另一方面，在某些感染中报告抗体依赖性增强等副作用限制了其使用。
