Jones Daniel P, Richardson Tom G, Davey Smith George, Gunnell David, Munafò Marcus R, Wootton Robyn E
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Southmead Hospital, Westbury-on-Trym, Bristol, UK.
Crohns Colitis 360. 2020 Mar 12;2(1):otaa018. doi: 10.1093/crocol/otaa018. eCollection 2020 Jan.
Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).
We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes.
In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD.
Overall, our results suggest that smoking does not causally influence the risk of IBD.
既往观察性证据提示吸烟与炎症性肠病（IBD）之间存在关联。
我们采用观察性技术，随后进行孟德尔随机化分析，以探究吸烟是否为IBD及其亚型发生的因果因素。
在曾经吸烟的人群中，我们观察到IBD风险增加；在当前吸烟者中，我们观察到克罗恩病风险增加，而溃疡性结肠炎风险降低。然而，我们的孟德尔随机化分析几乎没有发现吸烟影响IBD发生的证据。
总体而言，我们的结果提示吸烟不会因果性地影响IBD风险。
