Angersbach D, Jukna J J, Nicholson C D, Ochlich P, Wilke R
Beecham-Wülfing Research Laboratories, Gronau, Leine, FRG.
Int J Microcirc Clin Exp. 1988 Jan;7(1):15-30.
The effect of short-term (1 day-1 week) and long-term (6-12 weeks) femoral artery ligation on the oxygen tension (pO2), blood flow, metabolism and function of rat gastrocnemius muscle has been examined. Femoral artery ligation reduced resting blood flow, pO2 and pH. Concomitantly, the concentration of high energy phosphates was reduced and the muscle lactate concentration increased. The fatigue developed by the gastrocnemius/plantaris muscle, during a 10 min period of isometric exercise, was increased and the associated hyperaemia was attenuated. The surgery, performed to ligate the artery, induced an increase in the plasma fibrinogen concentration and whole blood viscosity. As the time interval increased after the femoral artery ligation there was a progressive reduction of the magnitude of the effects. Ten weeks after ligation resting muscle concentrations of high energy phosphates and lactate, whole blood viscosity and muscle pH had normalized. However, resting muscle blood flow, pO2, ability to sustained isometric exercise and the exercise induced hyperaemia were still reduced compared to intact animals. Comparison with literature data reveals that the changes produced by chronic femoral artery ligation in rat calf muscle mimic those seen in man with intermittent claudication.
研究了短期（1天至1周）和长期（6至12周）股动脉结扎对大鼠腓肠肌氧分压（pO2）、血流量、代谢及功能的影响。股动脉结扎使静息血流量、pO2和pH值降低。与此同时，高能磷酸盐浓度降低，肌肉乳酸浓度升高。在10分钟等长运动期间，腓肠肌/跖肌产生的疲劳增加，且相关的充血减弱。结扎动脉的手术导致血浆纤维蛋白原浓度和全血粘度增加。随着股动脉结扎后时间间隔的增加，这些影响的程度逐渐降低。结扎后十周，静息肌肉中的高能磷酸盐和乳酸浓度、全血粘度及肌肉pH值已恢复正常。然而，与完整动物相比，静息肌肉血流量、pO2、持续等长运动的能力及运动诱导的充血仍降低。与文献数据比较表明，大鼠小腿肌肉慢性股动脉结扎所产生的变化与人类间歇性跛行所见相似。
