Unit of Thoracic Surgery, General Surgery, Oncology Unit, Anaesthesiology Unit, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):362-365. doi: 10.26355/eurrev_202101_24403.
Pseudomyxoma peritonei (PMP) is an uncommon disease with locally-invasive attitude. Intrathoracic spread is rarely reported and its management extremely challenging. A 51-year-old Caucasian female presented with left pleural carcinosis 9-months after two sequential abdominal surgical procedures combined with HIPEC for low-grade PMP. Cytoreductive surgery (pleurectomy/decortication) was followed by 60-minutes hyperthermic intrathoracic chemotherapy mitomycin-C (215 mg/m2) infusing at same temperature (42°C) and intrapleural pression (2-4 mmH2O). No intra-operative complication occurred, the post-op stay was uneventful and no sign of recurrence was observed 9-months after surgery. Cytoreductive thoracic surgery and hyperthermic chemotherapy (HITHOC) could be a feasible therapeutic option in very selected cases.
腹膜假黏液瘤（PMP）是一种具有局部侵袭性的罕见疾病。胸腔内播散很少见，其治疗极具挑战性。一名 51 岁的白人女性在两次连续的腹部手术（联合 HIPEC 治疗低级别 PMP）后 9 个月出现左侧胸膜癌。行细胞减灭性手术（胸膜切除术/剥脱术）后，进行 60 分钟的高热胸腔内化疗，用丝裂霉素-C（215mg/m2）在相同温度（42°C）和胸腔内压（2-4mmHg）下输注。手术过程中未发生任何并发症，术后恢复顺利，术后 9 个月未观察到复发迹象。细胞减灭性胸部手术和高热化疗（HITHOC）可能是非常选择病例的一种可行治疗选择。
