Chan Leung, Chen Xiaodan, Gao Pan, Xie Jun, Zhang Zhongyang, Zhao Jianfu, Chen Tianfeng
Department of Oncology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China.
ACS Nano. 2021 Feb 23;15(2):3047-3060. doi: 10.1021/acsnano.0c09454. Epub 2021 Jan 28.
Coordination-driven surface modification is an effective strategy to achieve nanosystem functionalization and improved physicochemical performance. Black phosphorus (BP)-based nanomaterials demonstrate great potential in cancer therapy, but their poor stability, low X-ray mass attenuation coefficient, and nonselectivity limit the application in radiotherapy. Herein, we used unsaturated iridium complex to coordinate with BP nanosheets to synthesize a two-dimensional layered nanosystem (RGD-Ir@BP) with higher biostability. Ir complex improves the photoelectric properties and photoinduced charge carrier dynamics of BP, hence Ir@BP generated more singlet oxygen after X-ray irradiation. In experiments, with X-ray irradiation, RGD-Ir@BP effectively inhibited nasopharyngeal carcinoma tumor growth but with minor side effects. Additionally, based on untargeted metabolomics analysis, the combined treatment specifically down-regulated the tumor proliferative mark of prostaglandin E2 in cancer cells. In general, this study provides a design strategy of high-performance coordination-driven BP-based nanosensitizer in cancer radiotherapy.
配位驱动的表面修饰是实现纳米系统功能化和改善物理化学性能的有效策略。基于黑磷（BP）的纳米材料在癌症治疗中显示出巨大潜力，但其稳定性差、X射线质量衰减系数低和非选择性限制了其在放射治疗中的应用。在此，我们使用不饱和铱配合物与BP纳米片配位，合成了具有更高生物稳定性的二维层状纳米系统（RGD-Ir@BP）。铱配合物改善了BP的光电性能和光生载流子动力学，因此Ir@BP在X射线照射后产生了更多的单线态氧。在实验中，经X射线照射后，RGD-Ir@BP有效抑制了鼻咽癌肿瘤生长，且副作用较小。此外，基于非靶向代谢组学分析，联合治疗特异性下调了癌细胞中前列腺素E2的肿瘤增殖标志物。总体而言，本研究为癌症放射治疗中高性能配位驱动的基于BP的纳米增敏剂提供了一种设计策略。
