Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6099-6108. doi: 10.1021/acsami.0c22489. Epub 2021 Jan 28.
The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs.
血脑屏障（BBB）是一种物理屏障，可选择性地防止某些物质通过血液进入大脑。BBB 可保护大脑免受细菌侵害，并导致颅内治疗困难。化疗药物替莫唑胺（TMZ）嵌入纳米气泡（NBs）并与持续发光纳米颗粒（PLNs）结合，已通过图像跟踪成功用于治疗胶质母细胞瘤（GBM）。通过超声诱导，NBs 产生空化作用，暂时打开 BBB。此外，PLNs 释放近红外发射和余晖，可以穿透深部组织并提高生物图像的信噪比。在这项工作中，纳米系统穿过 BBB 进行药物输送并随时间进行图像跟踪，从而增强了药物对 GBM 的治疗效果。我们希望通过在 NBs 中嵌入不同的药物，该纳米系统可以应用于治疗不同的脑部疾病。
