Department of Process Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Telangana, India.
Org Biomol Chem. 2021 Feb 25;19(7):1438-1458. doi: 10.1039/d0ob02309d.
In the past two decades, transition metal-catalyzed C-H functionalization followed by annulations with various coupling partners has received much attention in organic synthesis. In particular, Rh(iii) or Ir(iii) catalyzed regioselective C-H functionalization followed by the cyclization of diverse arenes with metal carbene precursors has become a highly investigated research field in recent years. The purpose of this review is to provide a comprehensive essay on the Rh(iii)/Ir(iii) catalyzed C-H functionalizations/annulations via carbene migratory insertion, focusing on the diverse metal carbene precursors with arenes/alkenes reported so far. The highlighted examples are categorized by nitrogen, oxygen, sulfur-containing heterocycles and carbocyclizations. Further, key mechanistic approaches are also briefly described.
在过去的二十年中，过渡金属催化的 C-H 功能化反应，随后与各种偶联试剂进行环化反应，在有机合成中受到了广泛关注。特别是 Rh(iii)或 Ir(iii)催化的区域选择性 C-H 功能化反应，随后与金属卡宾前体的各种芳烃进行环化反应，近年来已成为一个备受研究的领域。本综述的目的是提供一篇全面的论文，综述 Rh(iii)/Ir(iii)催化的通过卡宾迁移插入的 C-H 功能化/环化反应，重点介绍迄今为止报道的各种芳烃/烯烃的金属卡宾前体。突出的例子按含氮、氧、硫的杂环和碳环化进行分类。此外，还简要描述了关键的机理方法。
