血管生成对肿瘤发展的影响：临床前研究的系统评价和荟萃分析。

The effects of vascularization on tumor development: A systematic review and meta-analysis of pre-clinical studies.

机构信息

Department of Physical Medicine and Rehabilitation, Hospital-Escola, Fernando Pessoa University, Avenida Fernando Pessoa 150, 4420-096 Gondomar, Portugal; Laboratory of Biochemistry and Experimental Morphology, CIAFEL, R. Dr. Plácido Costa 91, 4200-450 Porto, Portugal.

Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

出版信息

Crit Rev Oncol Hematol. 2021 Mar;159:103245. doi: 10.1016/j.critrevonc.2021.103245. Epub 2021 Jan 27.

DOI:10.1016/j.critrevonc.2021.103245

PMID:33508446

Abstract

PURPOSE

This review aimed to systematize and quantify the existing evidence about the effect of tumor vascularization on its growth, in preclinical studies.

METHODOLOGY

A computerized research on databases PubMed, Scopus and EBSCO was performed to identify studies that evaluate both the vascularization parameters and the development of the tumors in animal models and the mean differences were calculated through a random effects model.

RESULTS

Thirteen studies met the inclusion criteria and were included in the systematic review, of which, 6 studies were included in the meta-analysis. Besides tumor vascular density that all studies evaluated, 3 studies analysed the tumor perfusion, 2 studies the tumor hypoxia and 3 studies assessed the grade of vessel maturation. Most of the studies (11) related decreased tumor vascularization and a concomitant inhibition of tumor growth or metastasis development. Quantitatively, the decrease in tumor vascularization contributed to a significant decrease in the tumor growing rate of 5.23 (-9.20, -1.26).

CONCLUSION

A reduced level of tumor vascularization seems to be able to inhibit tumor growth and progression.

摘要

目的

本综述旨在系统地总结和量化肿瘤血管生成对其生长的影响的现有证据，这些研究均来自于临床前研究。

方法

通过计算机检索 PubMed、Scopus 和 EBSCO 数据库，以确定评估动物模型中血管生成参数和肿瘤发展的研究，并通过随机效应模型计算平均值差异。

结果

符合纳入标准并被纳入系统评价的研究共有 13 项，其中 6 项研究被纳入荟萃分析。除了所有研究评估的肿瘤血管密度外，还有 3 项研究分析了肿瘤灌注，2 项研究分析了肿瘤缺氧，3 项研究评估了血管成熟度的分级。大多数研究（11 项）表明肿瘤血管生成减少，同时抑制肿瘤生长或转移发展。定量分析表明，肿瘤血管生成减少可使肿瘤生长速度显著降低 5.23（-9.20，-1.26）。