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"FLAMES:MOG IgG 相关疾病中的一种新型燃烧实体"。

"FLAMES: A novel burning entity in MOG IgG associated disease".

机构信息

Department of Neurology, Sree Chitra Tirunal institute for Medical Sciences and Technology, Kerala, India.

Department of Neuropathology, Sree Chitra Tirunal institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

出版信息

Mult Scler Relat Disord. 2021 Apr;49:102759. doi: 10.1016/j.msard.2021.102759. Epub 2021 Jan 17.

Abstract

FLAMES is a new clinico-radiological sub entity of myelin oligodendrocyte glycoprotein (MOG) antibody associated disease (MOGAD). FLAMES is characterized by fluid attenuated inversion recovery (FLAIR) imaging showing hyperintense cortical lesions, in MOG associated Encephalitis with Seizures. MOGAD usually presents with optic neuritis, myelitis or acute disseminated encephalomyelitis and such rare focal cortical encephalitis like presentation can be mistaken as due to viral aetiology. FLAMES can present with unilateral or bilateral cortical encephalitis and we report a case where magnetic resonance angiography, susceptibility weighted imaging and perfusion studies were done and the utility of these additional imaging markers in diagnosing FLAMES is discussed.

摘要

FLAMES 是髓鞘少突胶质细胞糖蛋白(MOG)抗体相关疾病(MOGAD)的一种新的临床放射学亚型。FLAMES 的特征是在 MOG 相关脑炎伴发癫痫中,液体衰减反转恢复(FLAIR)成像显示皮质高信号病变。MOGAD 通常表现为视神经炎、脊髓炎或急性播散性脑脊髓炎,这种罕见的局灶性皮质脑炎样表现可能被误认为是病毒病因。FLAMES 可表现为单侧或双侧皮质脑炎,我们报告了一例患者,对其进行了磁共振血管造影、磁敏感加权成像和灌注研究,并讨论了这些额外成像标志物在诊断 FLAMES 中的作用。

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