Jhon Min, Kim Ju-Wan, Kang Hee-Ju, Kim Seon-Young, Lee Ju-Yeon, Kim Sung-Wan, Shin Il-Seon, Kim Jae-Min
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Clin Psychopharmacol Neurosci. 2021 Feb 28;19(1):166-169. doi: 10.9758/cpn.2021.19.1.166.
Psychiatric side effects of oseltamivir can result in accident-proneness and suicide. Reportedly, such adverse psychiatric events are more common in children than in adults, but other risk factors are not known. We present a 13-year-old girl with influenza infection who developed manic symptoms after taking oseltamivir and receiving the human papillomavirus vaccination. While other research has found that psychiatric side effects associated with oseltamivir generally occur within 48 hours after beginning administration, in this case the manic symptoms developed on the fourth day after cessation of 5-day course of oseltamivir administration. Based on our review of this case, we recommend that clinicians should carry out vigilant monitoring of each patient's mental state when the patient is young, has a family history of psychiatric disorder, has drug sensitivity and has received medical treatments such as vaccination before or after taking oseltamivir. In addition, as side effects of oseltamivir may occur more than 48 hours after administration, it will be necessary to observe patients for several days after the prescription of oseltamivir.
奥司他韦的精神科副作用可导致易出事故倾向和自杀。据报道，此类不良精神事件在儿童中比在成人中更常见，但其他风险因素尚不清楚。我们报告一名13岁患流感的女孩，在服用奥司他韦并接种人乳头瘤病毒疫苗后出现躁狂症状。虽然其他研究发现，与奥司他韦相关的精神科副作用一般在开始用药后48小时内出现，但在本例中，躁狂症状在奥司他韦5天疗程停药后的第4天出现。基于我们对该病例的回顾，我们建议临床医生在患者年幼、有精神疾病家族史、有药物敏感性以及在服用奥司他韦之前或之后接受过疫苗接种等医疗治疗时，应对每位患者的精神状态进行密切监测。此外，由于奥司他韦的副作用可能在用药后48小时以上出现，因此在开具奥司他韦处方后有必要对患者进行数天的观察。
